Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.45 |
| ▸ | SIK1 | P57059 | 9/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 9/20 | 0.45 |
| ▸ | SIK3 | Q9Y2K2 | 9/20 | 0.45 |
| ▸ | ABL1 | P00519 | 8/20 | 0.45 |
| ▸ | LYN | P07948 | 8/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 8/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210384 | 0.83 | MAPK1 (0.43) | MAPK1MKNK1MKNK2CHEK1CHEK2 | |
| SCHEMBL15212570 | 0.80 | MKNK1 (0.42) | MAPK1MKNK1MKNK2FLT4KDR | |
| SCHEMBL15210434 | 0.79 | CAMKK2 (0.39) | MAPK1MKNK1MKNK2FLT3CHEK1 | |
| SCHEMBL15210462 | 0.78 | CAMKK2 (0.42) | ABL1LYNMAPK1MKNK1MKNK2 | |
| SCHEMBL15210343 | 0.77 | GAA (0.41) | MAPK1MKNK1MKNK2KDRCHEK1 | |
| SCHEMBL15210438 | 0.77 | SLC9A1 (0.43) | MAPK1MKNK1MKNK2CHEK1CHEK2 | |
| SCHEMBL724725 | 0.77 | PRKAB2 (0.42) | CSF1RSIK1SIK2SIK3ABL1 | |
| SCHEMBL15210498 | 0.77 | AR (0.38) | SYKMAPK1MKNK1MKNK2FLT4 | |
| SCHEMBL15210587 | 0.76 | AR (0.44) | MAPK1MKNK1MKNK2FLT3CHEK1 | |
| SCHEMBL15210505 | 0.76 | CAMKK2 (0.38) | SYKMAPK1MKNK1MKNK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817313-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | claimed |
| EP-2817313-A1 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | claimed |
| WO-2013124025-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | claimed |
| EP-2817313-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | disclosed |
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | US | disclosed |
| EP-2817313-A1 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013124025-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | SYK, LYN, BTK | CSF1R 107/4885SIK1 1236/4885SIK2 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.