Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211233 | 0.83 | POLB (0.34) | POLBPTPN1HTR2CMEN1KMT2A | |
| SCHEMBL15211128 | 0.78 | POLB (0.40) | POLBMEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL15211580 | 0.77 | POLB (0.39) | POLBMEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL435247 | 0.77 | POLB (0.39) | POLBMEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL530687 | 0.77 | POLB (0.39) | POLBMEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL1707736 | 0.72 | POLB (0.38) | POLBMEN1KMT2A | |
| SCHEMBL15211457 | 0.71 | HDAC8 (0.41) | POLBMEN1KMT2A | |
| SCHEMBL1708186 | 0.70 | MAPT (0.42) | POLBMEN1KMT2A | |
| SCHEMBL1707740 | 0.65 | HSD11B1 (0.41) | POLBGABRA1GABRB2 | |
| SCHEMBL27213501 | 0.61 | POLB (0.38) | POLBMEN1KMT2AGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838891-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013125732-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-29 | — | — | WO | disclosed |