Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211580 | 0.84 | POLB (0.39) | POLBALDH1A1ESR1HSD17B10MEN1 | |
| SCHEMBL530687 | 0.84 | POLB (0.39) | POLBALDH1A1ESR1HSD17B10MEN1 | |
| SCHEMBL435247 | 0.84 | POLB (0.39) | POLBALDH1A1ESR1HSD17B10MEN1 | |
| SCHEMBL15211128 | 0.76 | POLB (0.40) | POLBALOX5ALDH1A1ESR1HSD17B10 | |
| SCHEMBL1707740 | 0.74 | HSD11B1 (0.41) | POLB | |
| SCHEMBL15211525 | 0.72 | POLB (0.34) | POLBMEN1KMT2A | |
| SCHEMBL15211233 | 0.72 | POLB (0.34) | POLBMEN1KMT2A | |
| SCHEMBL1707872 | 0.71 | CHRNB4 (0.36) | POLBALDH1A1ESR1HSD17B10GAA | |
| SCHEMBL15211497 | 0.69 | SLC26A4 (0.39) | POLBESR1MEN1KMT2A | |
| SCHEMBL15211108 | 0.69 | MCL1 (0.32) | POLBALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |