Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211580 | 0.72 | POLB (0.39) | ALDH1A1MEN1KMT2AMAPK1TDP1 | |
| SCHEMBL530687 | 0.72 | POLB (0.39) | ALDH1A1MEN1KMT2AMAPK1TDP1 | |
| SCHEMBL435247 | 0.72 | POLB (0.39) | ALDH1A1MEN1KMT2AMAPK1TDP1 | |
| SCHEMBL15211525 | 0.70 | POLB (0.34) | MEN1KMT2APOLB | |
| SCHEMBL10010062 | 0.69 | FFAR1 (0.48) | MAPTGAAMEN1KMT2APLA2G1B | |
| SCHEMBL10010057 | 0.69 | FFAR1 (0.48) | MAPTGAAMEN1KMT2APLA2G1B | |
| SCHEMBL1707736 | 0.69 | POLB (0.38) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1708581 | 0.67 | POLB (0.31) | MAPTTP53MEN1KMT2AKDM4E | |
| SCHEMBL15211128 | 0.66 | POLB (0.40) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL14337417 | 0.65 | SIRT2 (0.56) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |