Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL530687 | 1.00 | POLB (0.39) | POLBGABRA1GABRB2ESR1ESR2 | |
| SCHEMBL435247 | 1.00 | POLB (0.39) | POLBGABRA1GABRB2ESR1ESR2 | |
| SCHEMBL15211128 | 0.89 | POLB (0.40) | POLBGABRA1GABRB2ESR1ESR2 | |
| SCHEMBL1707736 | 0.84 | POLB (0.38) | POLBESR1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL15211497 | 0.80 | SLC26A4 (0.39) | POLBESR1ESR2MEN1KMT2A | |
| SCHEMBL15211233 | 0.77 | POLB (0.34) | POLBGABRA1GABRB2MEN1KMT2A | |
| SCHEMBL15211525 | 0.77 | POLB (0.34) | POLBGABRA1GABRB2MEN1KMT2A | |
| SCHEMBL1707740 | 0.75 | HSD11B1 (0.41) | POLBGABRA1GABRB2AKR1C3CA2 | |
| SCHEMBL9749477 | 0.75 | ESR1 (0.41) | ESR1ESR2CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL1708186 | 0.72 | MAPT (0.42) | POLBALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838891-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013125732-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-29 | — | — | WO | disclosed |