Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211695 | 0.91 | UBE2M (0.35) | PPARGPPARDPPARANFE2L2AHR | |
| SCHEMBL15211872 | 0.91 | NFE2L2 (0.38) | PPARGPPARDPPARANFE2L2AHR | |
| SCHEMBL15211665 | 0.89 | AHR (0.46) | PPARGPPARDPPARAAHRRAPGEF4 | |
| SCHEMBL15211460 | 0.86 | CYP1A1 (0.42) | AHRPTGS1 | |
| SCHEMBL12505799 | 0.76 | IDO1 (0.41) | IDO1PPARGPPARDPPARANFE2L2 | |
| SCHEMBL2097827 | 0.75 | RPS6KA3 (0.41) | IDO1PPARGPPARDPPARANFE2L2 | |
| SCHEMBL18187457 | 0.75 | ALDH1A1 (0.42) | IDO1PPARGPPARDPPARANFE2L2 | |
| SCHEMBL16829586 | 0.75 | IDO1 (0.39) | IDO1PPARGPPARDPPARANFE2L2 | |
| SCHEMBL16829643 | 0.75 | IDO1 (0.39) | IDO1PPARGPPARDPPARANFE2L2 | |
| SCHEMBL6553356 | 0.75 | ALDH1A1 (0.42) | IDO1PPARGPPARDPPARANFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817312-A1 | NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS | Leo Pharma A/S (DK) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013124286-A1 | NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS | LEO PHARMA A/S (DK) | 2013-08-29 | — | — | WO | disclosed |