Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800996 | 0.80 | ALPL (0.45) | ALPLALDH1A1KDM4ESMN1; SMN2AKR1B1 | |
| SCHEMBL15212224 | 0.80 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL56146 | 0.79 | ALDH1A1 (0.51) | ALPLALDH1A1KDM4ESMN1; SMN2AKR1B1 | |
| SCHEMBL8634618 | 0.76 | NPC1 (0.46) | ALPLALDH1A1KDM4ESMN1; SMN2AKR1B1 | |
| SCHEMBL3715441 | 0.75 | ALPL (0.48) | ALPLALDH1A1AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL13007730 | 0.74 | ALPL (0.47) | ALPLALDH1A1AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL2104226 | 0.73 | TRPV1 (0.47) | ALPLALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL8801637 | 0.72 | ALPL (0.41) | ALPLALDH1A1KDM4ESMN1; SMN2AKR1B1 | |
| SCHEMBL8799897 | 0.72 | ALPL (0.45) | ALPLALDH1A1AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL13253436 | 0.72 | ALPL (0.48) | ALPLALDH1A1AKR1B1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817306-B1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-09-16 | — | — | EP | disclosed |
| EP-2817306-B1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-09-16 | — | — | EP | disclosed |
| US-9073944-B2 | Cyclic diaminopyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-9073944-B2 | Cyclic diaminopyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-9073944-B2 | Cyclic diaminopyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-20150025066-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| US-20150025066-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| US-20150025066-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| EP-2817306-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | disclosed |
| CN-104254531-A | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH | 2014-12-31 | — | — | CN | disclosed |
| WO-2013126132-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |
| WO-2013126132-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025066-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | SYK, BTK, LYN | ALPL 3107/4885ALDH1A1 513/4885KDM4E 1067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.