Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.36 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56146 | 0.77 | ALDH1A1 (0.51) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL3715441 | 0.76 | ALPL (0.48) | ALPLKDM1AAKR1B1CAPN9CASP3 | |
| SCHEMBL8799331 | 0.75 | MAPT (0.44) | ALPLKDM1AAKR1B1ALDH1A1PGR | |
| SCHEMBL8799897 | 0.73 | ALPL (0.45) | ALPLKDM1AAKR1B1CAPN9CASP3 | |
| SCHEMBL8800996 | 0.73 | ALPL (0.45) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL15212007 | 0.72 | ALPL (0.43) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL13007730 | 0.72 | ALPL (0.47) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL17708209 | 0.72 | ALPL (0.37) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL8634618 | 0.72 | NPC1 (0.46) | ALPLAKR1B1CAPN9CASP3ALDH1A1 | |
| SCHEMBL2104226 | 0.71 | TRPV1 (0.47) | ALPLALDH1A1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700798-A | Methods for using benzoxazines for treating asthma | ZENECA LIMITED (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0698022-B1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1997-09-17 | — | — | EP | disclosed |
| EP-0698022-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5486515-A | 2-fluoroalkyl-1,4-benzoxaxines as potassium channel mediators | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| WO-1994026739-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |