SCHEMBL660308

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL10346581	0.88	JAK2 (0.70)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL10192774	0.87	JAK2 (0.69)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL13555628	0.87	JAK2 (0.72)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL7465716	0.84	ACVR1 (0.70)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL10246893	0.83	JAK2 (0.64)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL7476832	0.83	JAK2 (0.72)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL15212479	0.83	JAK2 (0.76)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL12325149	0.82	BRD4 (0.64)	JAK2JAK3CDK2CCNE1CDK4
	SCHEMBL10245770	0.82	JAK2 (0.62)	JAK2STK17AJAK3HDAC1HDAC6
	SCHEMBL4383450	0.82	JAK2 (1.00)	JAK2JAK3HDAC1HDAC6IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.