Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.58 |
| ▸ | SCN1A | P35498 | 3/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL29071811 | 0.98 | SLC6A2 (0.57) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL17071880 | 0.81 | SLC6A2 (0.67) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL290075 | 0.81 | SLC6A2 (0.67) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL23689568 | 0.79 | TSHR (0.48) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL10203032 | 0.79 | TSHR (0.48) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL9493121 | 0.77 | HRH1 (0.54) | SLC6A2SLC6A4CHRM2SLC6A3ALDH1A1 | |
| SCHEMBL11599476 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL6377512 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL1422822 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL4796436 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A4CHRM2SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233156-B2 | 9-membered fused ring derivative | SHIONOGI & CO., LTD. (JP) | 2019-03-19 | — | — | US | disclosed |
| US-9579325-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-9579325-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150126512-A1 | Modulators Of TNF-Alpha Signaling | GENZYME CORPORATION (US) | 2015-05-07 | — | — | US | disclosed |
| US-8921547-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130310388-A1 | Modulators of TNF-Alpha Signaling | GENZYME CORPORATION (US) | 2013-11-21 | — | — | US | disclosed |
| US-8518999-B2 | Modulators of TNF-αsignaling | GENZYME CORPORATION (US) | 2013-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126512-A1 | Modulators Of TNF-Alpha Signaling | TNF, TNFRSF1A, TNFRSF9 | SLC6A2 3922/4885SLC6A4 4110/4885CHRM2 1547/4885 |
| US-10233156-B2 | 9-membered fused ring derivative | AGTR2, ACSS2, ACSL3 | SLC6A2 1663/4885SLC6A4 3177/4885CHRM2 158/4885 |
| US-20130310388-A1 | Modulators of TNF-Alpha Signaling | TNF, TNFRSF1A, TNFRSF9 | SLC6A2 3922/4885SLC6A4 4110/4885CHRM2 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.