Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209985 | 1.00 | TDP1 (0.44) | TDP1TSPOLDHAMEN1KMT2A | |
| SCHEMBL15215178 | 0.85 | TSHR (0.43) | TDP1MEN1KMT2AACHEALDH1A1 | |
| SCHEMBL15209869 | 0.82 | APLNR (0.44) | TDP1TSPOLDHAACHEALDH1A1 | |
| SCHEMBL15209867 | 0.82 | APLNR (0.44) | TDP1TSPOLDHAACHEALDH1A1 | |
| SCHEMBL15209900 | 0.74 | LDHA (0.50) | TDP1TSPOLDHAMEN1KMT2A | |
| SCHEMBL15209971 | 0.72 | LDHA (0.49) | TDP1TSPOLDHAMEN1KMT2A | |
| SCHEMBL20472046 | 0.71 | ALDH1A1 (0.52) | TDP1LDHAMEN1KMT2AACHE | |
| SCHEMBL3484433 | 0.70 | TDP1 (0.60) | TDP1LDHAMEN1KMT2AACHE | |
| SCHEMBL15215173 | 0.70 | ACHE (0.43) | TDP1MEN1KMT2AACHEALDH1A1 | |
| SCHEMBL20472138 | 0.69 | LDHA (0.45) | TDP1LDHAMEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458177-B2 | Oxazolidin-2-one compounds and uses thereof | NOVARTIS AG (CH) | 2016-10-04 | — | — | US | disclosed |
| EP-2817307-B1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF AS PI3KS INHIBITORS | NOVARTIS AG (CH) | 2016-07-13 | — | — | EP | disclosed |
| EP-2817307-A1 | OXAZOLIDIN- 2 -ONE COMPOUNDS AND USES THEREOF AS PI3KS INHIBITORS | Novartis AG (CH) | 2014-12-31 | — | — | EP | disclosed |
| US-20140378450-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2014-12-25 | — | — | US | disclosed |
| WO-2013124826-A1 | OXAZOLIDIN- 2 -ONE COMPOUNDS AND USES THEREOF AS PI3KS INHIBITORS | NOVARTIS AG (CH) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378450-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | TDP1 860/4885TSPO 3134/4885LDHA 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.