Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 11/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 8/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desmetramadol SCHEMBL12125413 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL2517055 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL4396391 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL4396389 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL2518899 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL7882257 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| Desmetramadol SCHEMBL2410234 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948058 | 0.93 | OPRM1 (0.95) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948069 | 0.92 | SLC6A4 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948086 | 0.91 | SLC6A4 (0.84) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 529 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117110457-A | Analysis method for screening 50 new pollutants in sewage by micro-volume direct sample injection technology | 司法鉴定科学研究院 | 2023-11-24 | — | — | CN | claimed |
| US-20230330042-A1 | FORMULATION FOR ORAL ADMINISTRATION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2023-10-19 | — | — | US | claimed |
| EP-4218747-A1 | FORMULATION FOR ORAL ADMINISTRATION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2023-08-02 | — | — | EP | claimed |
| CN-116194092-A | Oral administration preparation | 日本脏器制药株式会社 | 2023-05-30 | — | — | CN | claimed |
| US-20210299045-A1 | TRAMADOL HYDROCHLORIDE SOLUTION | ROSEMONT PHARMACEUTICALS LLC | 2021-09-30 | — | — | US | claimed |
| US-20210137835-A1 | Tramadol Hydrochloride Solution | ROSEMONT PHARMACEUTICALS LLC | 2021-05-13 | — | — | US | claimed |
| CN-112007024-A | Use of combinations of ereoxib and tramadol for preparing a medicament for treating pain | 江苏恒瑞医药股份有限公司 | 2020-12-01 | — | — | CN | claimed |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | R L FINECHEM PRIVATE LIMITED (IN) | 2020-09-22 | — | — | US | claimed |
| EP-3684753-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L Fine Chem Private Limited (IN) | 2020-07-29 | — | — | EP | claimed |
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L FINECHEM PRIVATE LIMITED (IN) | 2020-07-23 | — | — | US | claimed |
| US-20090246816-A1 | METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME | KNOX MALCOLM | 2009-10-01 | — | — | US | claimed |
| EP-2052257-A1 | METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME | Knox, Geoffrey Malcolm (GB) | 2009-04-29 | — | — | EP | claimed |
| US-20090047345-A9 | Sustained-release tramadol formulations with 24-hour efficacy | ENDO OPERATIONS LIMITED (IE) | 2009-02-19 | — | — | US | claimed |
| EP-1917000-A2 | SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS FOR HIGHLY WATER SOLUBLE DRUGS | Farnam Companies, Inc. (US) | 2008-05-07 | — | — | EP | claimed |
| WO-2008009962-A1 | METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME | KNOX GEOFFREY MALCOLM (GB) | 2008-01-24 | — | — | WO | claimed |
| US-20070020335-A1 | Sustained release pharmaceutical compositions for highly water soluble drugs | FARNAM COMPANIES, INC. (US) | 2007-01-25 | — | — | US | claimed |
| WO-2007008752-A2 | SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS FOR HIGHLY WATER SOLUBLE DRUGS | FARNAM COMPANIES, INC. (US) | 2007-01-18 | — | — | WO | claimed |
| US-20070003618-A1 | Sustained-release tramadol formulations with 24-hour efficacy | LABOPHARM EUROPE LIMITED - PARTIAL INTEREST (ENTIRE INTEREST OWNED BY LABOPHARM INC., LABOPHARM EUROPE LIMITED, AND LABOPHARM (BARBADOS) LIMITED) (IE) | 2007-01-04 | — | — | US | claimed |
| EP-1594460-A2 | SUSTAINED-RELEASE TRAMADOL FORMULATIONS WITH 24-HOUR EFFICACY | LABOPHARM INC. (CA) | 2005-11-16 | — | — | EP | claimed |
| WO-2004037222-A2 | SUSTAINED-RELEASE TRAMADOL FORMULATIONS WITH 24-HOUR EFFICACY | LABOPHARM INC. (CA) | 2004-05-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | CYP3A7, TET1, CYP3A4 | OPRM1 84/4885SLC6A4 123/4885SLC6A2 109/4885 |
| US-20070020335-A1 | Sustained release pharmaceutical compositions for highly water soluble drugs | ABCG2, ABCB11, SLC7A5 | OPRM1 1002/4885SLC6A4 197/4885SLC6A2 111/4885 |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | TET1, TET2, TET3 | OPRM1 144/4885SLC6A4 160/4885SLC6A2 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.