Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28008389 | 0.80 | BRD4 (0.34) | ELANEMEN1KMT2APLCG1 | |
| SCHEMBL18785781 | 0.77 | ELANE (0.42) | ELANEGAAMAPT | |
| SCHEMBL11717509 | 0.76 | ELANE (0.47) | ELANE | |
| SCHEMBL1291212 | 0.75 | KDM4E (0.43) | ELANEMAPTMEN1KMT2A | |
| SCHEMBL1161075 | 0.74 | KMT2A (0.37) | GAAMAPTMEN1KMT2A | |
| SCHEMBL29100881 | 0.74 | TSHR (0.41) | GAAMAPT | |
| SCHEMBL19771464 | 0.74 | CHRM2 (0.43) | ELANEKMT2APLCG1 | |
| SCHEMBL6157107 | 0.72 | LMNA (0.39) | MAPTMEN1KMT2A | |
| SCHEMBL6919963 | 0.71 | ELANE (0.50) | ELANEMAPT | |
| Methylamine SCHEMBL536416 | 0.71 | KDM4E (0.41) | ELANEMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008339-B2 | Substituted pyrazole compounds containing pyrimidine and preparation method and use thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-05-18 | — | — | US | disclosed |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
| US-20180141961-A1 | Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| US-20180141961-A1 | Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| US-9682962-B2 | Pyrazolyl pyrimidinamine compound and application thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-9682962-B2 | Pyrazolyl pyrimidinamine compound and application thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20130225585-A1 | PYRAZOLE AMIDE COMPOUNDS AND USES THEREOF | SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225585-A1 | PYRAZOLE AMIDE COMPOUNDS AND USES THEREOF | BROX, OAT, CAT | ELANE 3895/4885GAA 489/4885MAPT 288/4885 |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | GART, BROX, APRT | ELANE 4374/4885GAA 2169/4885MAPT 665/4885 |
| US-20180141961-A1 | Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof | APRT, GART, PNP | ELANE 3827/4885GAA 1314/4885MAPT 1009/4885 |
| US-11008339-B2 | Substituted pyrazole compounds containing pyrimidine and preparation method and use thereof | APRT, GART, PNP | ELANE 3827/4885GAA 1314/4885MAPT 1009/4885 |
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | CTRC, APRT, MASTL | ELANE 1694/4885GAA 1138/4885MAPT 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.