Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 5/20 | 0.58 |
| ▸ | CCKAR | P32238 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255303 | 0.96 | CCKBR (0.56) | CCKBRCCKARCTSLHDAC8CTSS | |
| SCHEMBL8251244 | 0.93 | ACE (0.64) | CCKBRCCKARCTSLCTSSCTSK | |
| SCHEMBL15220102 | 0.92 | CTSL (0.61) | CCKBRCCKARCTSLCTSSCTSK | |
| SCHEMBL12706438 | 0.90 | REN (0.60) | CCKBRCTSLHDAC8CTSSCTSK | |
| SCHEMBL12706440 | 0.90 | CCKBR (0.63) | CCKBRCTSLHDAC8CTSSCTSK | |
| SCHEMBL15220261 | 0.89 | MAPT (0.61) | CCKBRCCKARCTSLHDAC8CTSS | |
| SCHEMBL8255302 | 0.89 | CCKBR (0.59) | CCKBRCCKARCTSLCTSSCTSK | |
| SCHEMBL8251042 | 0.89 | CCKBR (0.59) | CCKBRCCKARCTSLHDAC8CTSS | |
| SCHEMBL12706460 | 0.87 | REN (0.58) | CCKBRCTSLCTSSCTSKMAPT | |
| SCHEMBL8258464 | 0.87 | PSMB8 (0.60) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865950-B1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NAT RECH SCIENT (FR) | 2013-08-28 | — | — | EP | disclosed |