Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 4/20 | 0.35 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 4/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | STK17B | O94768 | 3/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565103 | 0.75 | POLB (0.45) | — | |
| SCHEMBL15225860 | 0.73 | SLC6A3 (0.35) | MAP3K8STK17BCHEK1SMN1; SMN2MCHR1 | |
| SCHEMBL3626959 | 0.72 | POLB (0.47) | — | |
| SCHEMBL15225861 | 0.69 | HTT (0.41) | MAPK1SMN1; SMN2 | |
| SCHEMBL3565107 | 0.69 | STK17B (0.38) | MAP3K8STK17BMAPK1MCHR1 | |
| SCHEMBL5089101 | 0.67 | STK17B (0.36) | MAP3K8STK17BSMN1; SMN2 | |
| SCHEMBL3567024 | 0.64 | EGFR (0.41) | EGFRFLT1SRCMETKDR | |
| SCHEMBL3567019 | 0.64 | EGFR (0.41) | EGFRFLT1SRCMETKDR | |
| SCHEMBL13185371 | 0.64 | MCHR1 (0.56) | EGFRFLT1SRCMCHR1 | |
| SCHEMBL2533961 | 0.63 | MCHR1 (0.32) | EGFRFLT1MAP3K8SRCSTK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |