Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565107 | 0.79 | STK17B (0.38) | HPGDALDH1A1KDM4EPKMMAPK1 | |
| SCHEMBL15225860 | 0.76 | SLC6A3 (0.35) | SMN1; SMN2NPC1RAB9ATDP1KMT2A | |
| SCHEMBL5089101 | 0.75 | STK17B (0.36) | ALDH1A1KDM4ESMN1; SMN2POLBLMNA | |
| SCHEMBL3565103 | 0.74 | POLB (0.45) | NPC1RAB9ATP53POLBMAPT | |
| SCHEMBL3626959 | 0.73 | POLB (0.47) | TP53POLBMAPT | |
| SCHEMBL15225858 | 0.69 | EGFR (0.35) | MAPK1SMN1; SMN2 | |
| SCHEMBL2533961 | 0.63 | MCHR1 (0.32) | NPC1RAB9ATDP1KMT2A | |
| SCHEMBL5242191 | 0.60 | CDC7 (0.43) | KDM4ESMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL17871637 | 0.60 | HPGD (0.64) | HPGDALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL3568858 | 0.60 | MCHR1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |