Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | STK17B | O94768 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.32 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15225861 | 0.76 | HTT (0.41) | SMN1; SMN2NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL3565107 | 0.74 | STK17B (0.38) | STK17BMAP3K8MCHR1KMT2A | |
| SCHEMBL15225858 | 0.73 | EGFR (0.35) | STK17BSMN1; SMN2CHEK1MAP3K8MCHR1 | |
| SCHEMBL5089101 | 0.70 | STK17B (0.36) | STK17BSMN1; SMN2MAP3K8KMT2A | |
| SCHEMBL3626959 | 0.67 | POLB (0.47) | — | |
| SCHEMBL2533961 | 0.63 | MCHR1 (0.32) | STK17BMAP3K8MCHR1KITNPC1 | |
| SCHEMBL6246290 | 0.62 | SLC6A3 (0.38) | SLC6A3SMN1; SMN2 | |
| SCHEMBL5242191 | 0.61 | CDC7 (0.43) | STK17BSMN1; SMN2MAP3K8MCHR1NPC1 | |
| SCHEMBL14831652 | 0.60 | TYK2 (0.54) | STK17BSMN1; SMN2MAP3K8MCHR1KIT | |
| SCHEMBL6002954 | 0.60 | IKBKB (0.54) | STK17BSMN1; SMN2MAP3K8MCHR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |