Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.60 |
| ▸ | FEN1 | P39748 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 3/20 | 0.45 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342005 | 0.85 | PDE1B (0.58) | ERCC5FEN1PDE1BMIFCD74 | |
| SCHEMBL1523605 | 0.78 | MIF (0.45) | ERCC5FEN1PDE1BCYP1A2CYP2C9 | |
| SCHEMBL1522913 | 0.76 | ERCC5 (0.41) | ERCC5FEN1PDE1BADORA2BCYP1A2 | |
| SCHEMBL1522332 | 0.75 | MIF (0.57) | MIFCD74ALDH1A1 | |
| SCHEMBL1883466 | 0.75 | ERCC5 (1.00) | ERCC5FEN1PDE1BADORA2BCYP1A2 | |
| SCHEMBL1523762 | 0.73 | ERCC5 (0.57) | ERCC5FEN1PDE1BADORA2BCYP1A2 | |
| SCHEMBL1523149 | 0.72 | MIF (0.53) | MIFCD74ALDH1A1 | |
| SCHEMBL5107600 | 0.72 | ERCC5 (0.58) | ERCC5FEN1PDE1BADORA2BPTGDR2 | |
| SCHEMBL27724198 | 0.72 | ERCC5 (0.61) | ERCC5FEN1PDE1BADORA2BPTGDR2 | |
| SCHEMBL20320843 | 0.71 | ERCC5 (0.39) | ERCC5FEN1ADORA2BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361913-A1 | Anti-infective agents | Abbott Laboratories (US) | 2011-08-31 | — | — | EP | disclosed |
| US-7902203-B2 | Anti-infective agents | ABBOTT LABORATORIES, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1560827-B1 | ANTI-INFECTIVE AGENTS | ABBOTT LAB (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20060229314-A1 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS | 2006-10-12 | — | — | US | disclosed |
| US-20050075331-A1 | Anti-infective agents | ABBOTT LABORATORIES | 2005-04-07 | — | — | US | disclosed |
| US-20040167123-A1 | Anti-infective agents | ABBVIE INC. | 2004-08-26 | — | — | US | disclosed |
| US-20040162285-A1 | Anti-infective agents | ABBOTT LABORATORIES | 2004-08-19 | — | — | US | disclosed |
| US-20040097492-A1 | Anti-infective agents | ABBOTT LABORATORIES | 2004-05-20 | — | — | US | disclosed |
| US-20040087577-A1 | Anti-infective agents | ABBOTT LABORATORIES | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097492-A1 | Anti-infective agents | POLR1C, RPL5, POLB | ERCC5 2973/4885FEN1 1213/4885PDE1B 4779/4885 |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | MIF, MMP12, MSR1 | ERCC5 4724/4885FEN1 2495/4885PDE1B 858/4885 |
| US-20060229314-A1 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | MIF, MMP12, MSR1 | ERCC5 4724/4885FEN1 2495/4885PDE1B 858/4885 |
| US-20040162285-A1 | Anti-infective agents | POLR1C, RPL5, POLB | ERCC5 2973/4885FEN1 1213/4885PDE1B 4779/4885 |
| US-20040167123-A1 | Anti-infective agents | SERPINB1, CYP51A1, ZC3HAV1 | ERCC5 3536/4885FEN1 727/4885PDE1B 4688/4885 |
| US-20050075331-A1 | Anti-infective agents | RPL35, POLI, POLRMT | ERCC5 3596/4885FEN1 1845/4885PDE1B 4718/4885 |
| US-20040087577-A1 | Anti-infective agents | POLR1C, RPL5, POLB | ERCC5 2973/4885FEN1 1213/4885PDE1B 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.