Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.46 |
| ▸ | KDR | P35968 | 12/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564192 | 0.83 | MET (0.64) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3577378 | 0.74 | MET (0.59) | METKDRFLT1FLT4AURKA | |
| SCHEMBL15225923 | 0.73 | ALDH1A1 (0.41) | METKDRALDH1A1FLT1FLT4 | |
| SCHEMBL3563267 | 0.69 | KDR (0.60) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3566528 | 0.66 | MET (0.60) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3570934 | 0.66 | MET (0.62) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL4328413 | 0.66 | MET (0.53) | METKDRCRHBPNPBWR1CRHR2 | |
| SCHEMBL4321802 | 0.65 | MET (0.54) | METKDRGAAMEN1KMT2A | |
| SCHEMBL3940540 | 0.64 | CRHBP (0.67) | CRHBPNPBWR1CRHR2MCHR1ALDH1A1 | |
| SCHEMBL3569273 | 0.63 | MET (0.60) | METKDRFLT1FLT4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |