Sugi Predict

Sugi Predict / Compounds / SCHEMBL15230494

SCHEMBL15230494

SCHEMBL15230494

O=C1Cc2cc(-c3cc(C(F)(F)F)cc4[nH]ncc34)cnc2N1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ METAP2 P50579 16/20 0.53
▸ CYP1A2 P05177 11/20 0.53
▸ GSK3B P49841 2/20 0.47
▸ CDK5 Q00535 2/20 0.47
▸ MET P08581 2/20 0.47
▸ CHEK1 O14757 1/20 0.47
▸ AURKA O14965 1/20 0.47
▸ DAPK3 O43293 1/20 0.47
▸ PRKD3 O94806 1/20 0.47
▸ MAP4K4 O95819 1/20 0.47
▸ ABL1 P00519 1/20 0.47
▸ NTRK1 P04629 1/20 0.47
▸ CSF1R P07333 1/20 0.47
▸ RET P07949 1/20 0.47
▸ PDGFRB P09619 1/20 0.47
▸ PIM1 P11309 1/20 0.47
▸ FGFR1 P11362 1/20 0.47
▸ PDGFRA P16234 1/20 0.47
▸ FLT1 P17948 1/20 0.47
▸ LTK P29376 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15230064 0.83 METAP2 (0.57) METAP2CYP1A2METKDRCDK1
SCHEMBL15230269 0.81 METAP2 (0.51) METAP2CYP1A2GSK3BCDK5GSK3A
SCHEMBL15230061 0.80 METAP2 (0.56) METAP2CYP1A2METTDP2
SCHEMBL15230282 0.76 METAP2 (0.54) METAP2CYP1A2SLC6A3GABRA1
SCHEMBL1396298 0.76 ABL1 (0.67) GSK3BCDK5METCHEK1AURKA
SCHEMBL15230527 0.74 METAP2 (0.56) METAP2CYP1A2GSK3BCDK5CHEK1
SCHEMBL15229811 0.73 METAP2 (0.63) METAP2CYP1A2SLC6A3GABRA1
SCHEMBL15230027 0.73 METAP2 (0.70) METAP2CYP1A2SLC6A3GABRA1
SCHEMBL15230111 0.72 METAP2 (0.66) METAP2CYP1A2SLC6A3GABRA1
SCHEMBL15230200 0.72 METAP2 (0.52) METAP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9434743-B2 Indazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-09-06 — — US claimed
US-20150005232-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) 2015-01-01 — — US claimed
WO-2013130855-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-09-06 — — WO claimed
US-9434743-B2 Indazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-09-06 — — US disclosed
US-9434743-B2 Indazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-09-06 — — US disclosed
US-9434743-B2 Indazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-09-06 — — US disclosed
US-20150005232-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) 2015-01-01 — — US disclosed
US-20150005232-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) 2015-01-01 — — US disclosed
US-20150005232-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) 2015-01-01 — — US disclosed
WO-2013130855-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-09-06 — — WO disclosed
WO-2013130855-A1 INDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-09-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150005232-A1 INDAZOLE DERIVATIVES GPR119, INSR, INSRR METAP2 46/4885CYP1A2 6/4885GSK3B 1536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.