Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 4/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 10/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923419 | 0.90 | CDK8 (0.47) | CDK8PLA2G7 | |
| SCHEMBL9900892 | 0.88 | PLA2G7 (0.54) | CDK8PLA2G7GPR84HDAC3HDAC4 | |
| SCHEMBL15277234 | 0.85 | KDM4E (0.40) | GPR84 | |
| SCHEMBL9923493 | 0.84 | PLA2G7 (0.47) | CDK8PLA2G7GPR84HDAC3HDAC4 | |
| SCHEMBL15261929 | 0.83 | PLA2G7 (0.43) | CDK8PLA2G7GPR84 | |
| SCHEMBL9923483 | 0.82 | PLA2G7 (0.44) | CDK8PLA2G7GPR84BRAF | |
| SCHEMBL9904370 | 0.82 | PLA2G7 (0.54) | CDK8PLA2G7 | |
| SCHEMBL9901511 | 0.80 | PLA2G7 (0.47) | CDK8PLA2G7GPR84HDAC3HDAC4 | |
| SCHEMBL9923492 | 0.78 | PLA2G7 (0.51) | PLA2G7GPR84 | |
| SCHEMBL14667698 | 0.76 | CTSS (0.47) | CDK8PLA2G7GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859573-B2 | Pyrimidinone and pyridinone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2 | GLAXO GROUP LIMITED (GB) | 2014-10-14 | — | — | US | disclosed |
| US-20130252986-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252986-A1 | COMPOUNDS | LIPG, ENPP2, PLA2G1B | CDK8 1764/4885PLA2G7 6/4885GPR84 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.