Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569768 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL15280430 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL16450976 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL18041161 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL15280428 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL15280427 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL16450981 | 0.82 | LMNA (0.67) | LMNAALDH1A1NPSR1POLBMAPT | |
| SCHEMBL5249642 | 0.78 | NPSR1 (0.50) | LMNAALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL15280576 | 0.77 | KMT2A (0.45) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL644252 | 0.74 | ALDH1A1 (0.53) | LMNAALDH1A1NPSR1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266490-B2 | Radioprotector compounds | GEORGETOWN UNIVERSITY (US) | 2019-04-23 | — | — | US | disclosed |
| US-20150044293-A1 | RADIOPROTECTOR COMPOUNDS | GEORGETOWN UNIVERSITY (US) | 2015-02-12 | — | — | US | disclosed |
| US-20150044293-A1 | RADIOPROTECTOR COMPOUNDS | GEORGETOWN UNIVERSITY (US) | 2015-02-12 | — | — | US | disclosed |
| WO-2013138600-A1 | RADIOPROTECTOR COMPOUNDS | ROSEN ELIOT M (US) | 2013-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266490-B2 | Radioprotector compounds | DDB1, CASP3, BAD | LMNA 649/4885ALDH1A1 1017/4885NPSR1 4294/4885 |
| US-20150044293-A1 | RADIOPROTECTOR COMPOUNDS | DDB1, CASP3, BAD | LMNA 649/4885ALDH1A1 1017/4885NPSR1 4294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.