Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380984 | 1.00 | ALDH1A1 (0.53) | ALDH1A1NPSR1LMNAGAAL3MBTL1 | |
| SCHEMBL644486 | 0.89 | ALDH1A1 (0.52) | ALDH1A1NPSR1LMNAGAAL3MBTL1 | |
| SCHEMBL6010342 | 0.87 | MMP1 (0.61) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL8384891 | 0.87 | MMP1 (0.61) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL926644 | 0.87 | NPSR1 (0.50) | ALDH1A1NPSR1LMNAGAAL3MBTL1 | |
| SCHEMBL927146 | 0.87 | ALDH1A1 (0.50) | ALDH1A1NPSR1LMNAL3MBTL1MCL1 | |
| SCHEMBL28751377 | 0.87 | LMNA (0.52) | ALDH1A1NPSR1LMNAL3MBTL1MCL1 | |
| SCHEMBL18041161 | 0.86 | LMNA (0.67) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL5569768 | 0.86 | LMNA (0.67) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL15280427 | 0.86 | LMNA (0.67) | ALDH1A1NPSR1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| US-20080312231-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
| EP-0861236-B2 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-08-16 | — | — | EP | disclosed |
| US-6815440-B2 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS IN THE COURSE OF WHICH IS INVOLVED AN INCREASED ACTIVITY OF MATRIX-DEGRADING METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-11-09 | — | — | US | disclosed |
| US-20030176432-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | AVENTIS PHARMA DEUTSCHLAND GMBH. | 2003-09-18 | — | — | US | disclosed |
| US-6573277-B2 | Metalloproteinase inhibitor | HOECHST AKTIENGESELLSCHAFT (DE) | 2003-06-03 | — | — | US | disclosed |
| EP-0861236-B1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AG (DE) | 2002-02-13 | — | — | EP | disclosed |
| US-20010011134-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | HOECHST AKTIENGESELLSCHAFT | 2001-08-02 | — | — | US | disclosed |
| US-6207672-B1 | FOR TREATMENT OF CONNECTIVE TISSUE DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-03-27 | — | — | US | disclosed |
| EP-0861236-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997018194-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED α-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010011134-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | MMP1, MMP2, HPGD | ALDH1A1 45/4885NPSR1 1086/4885LMNA 747/4885 |
| US-20080312231-A1 | Substituted Sulfonamide Compounds | SULT2A1, SULT1A1, SCN1A | ALDH1A1 511/4885NPSR1 39/4885LMNA 2721/4885 |
| US-20030176432-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | MMP1, MMP2, HPGD | ALDH1A1 45/4885NPSR1 1086/4885LMNA 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.