Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415431 | 0.88 | LMNA (0.47) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL229249 | 0.84 | RAB9A (0.40) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14000958 | 0.83 | ATM (0.41) | LMNATAAR1SMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL1107826 | 0.82 | ALDH1A1 (0.40) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6727852 | 0.80 | HSD17B10 (0.50) | LMNATAAR1SMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL10025870 | 0.79 | TAAR1 (0.37) | LMNATAAR1CYP3A4CYP2D6TSHR | |
| SCHEMBL1550836 | 0.77 | LMNA (0.41) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14000955 | 0.75 | LMNA (0.39) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12264064 | 0.73 | KDM4E (0.36) | LMNATAAR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1107835 | 0.73 | RAB9A (0.46) | LMNATAAR1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240468-B1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN INC (US) | 2013-10-16 | — | — | EP | disclosed |