Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL4274364 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL5959955 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL28165008 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL165374 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL8735136 | 0.86 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL29152718 | 0.86 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL347858 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL15366649 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL1456347 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL5872181 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CYP2A6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130273371-A1 | Process for Producing Monodisperse Polystyrene Micro-Particles | U.S.A. AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 2013-10-17 | — | — | US | disclosed |