Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL165374 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL28165008 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL4274364 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL15313172 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL29152718 | 0.91 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL8735136 | 0.91 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Diphenylether SCHEMBL27720609 | 0.88 | TSHR (0.52) | ALDH1A1TSHRTDP1CA2CA9 | |
| Styrene SCHEMBL28479724 | 0.87 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL2119541 | 0.87 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1CYP2A6HDAC8 | |
| Styrene SCHEMBL27724327 | 0.87 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1CYP2A6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114479779-A | Plugging agent for drilling fluid and preparation method thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-102504776-A | Lost circulation material for malignant loss and preparation method | UNIV SOUTHWEST PETROLEUM | 2012-06-20 | — | — | CN | disclosed |
| US-7128951-B2 | A substrate having fixed and aligned two layers of liquid crystalline compound there being no alignment layer between the two; the upper surface of the lower layer has a rubbed surface in contact with the upper layer; non-liqiuid crystal, crosslinkable polymer additive stability; displays; | FUJI PHOTO FILM CO., LTD. (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20040100600-A1 | Retarders, circular polarizer and processes for preparing them | FUJI PHOTO FILM CO., LTD. | 2004-05-27 | — | — | US | disclosed |
| EP-1391754-A1 | Retarders, circular polarizer and processes for preparing them | FUJI PHOTO FILM CO., LTD. (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-0784986-B1 | MAN-MADE HAIR FOR HAIR IMPLANTING AND PROCESS FOR PRODUCING THE SAME | YAMADA SHIRO (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-5800545-A | Artificial hair for implantation and process for producing the same | YAMADA SHIRO (JP) | 1998-09-01 | — | — | US | disclosed |
| EP-0784986-A1 | MAN-MADE HAIR FOR HAIR IMPLANTING AND PROCESS FOR PRODUCING THE SAME | Yamada, Shiro (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5032455-A | Silyated addition polymers with pendant ionic moieties | PPG INDUSTRIES, INC. (US) | 1991-07-16 | — | — | US | disclosed |
| US-4983699-A | Silylated addition polymers with pendant ionic moieties | PPG INDUSTRIES, INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0377188-A2 | Silylated addition polymers with pendant ionic moieties | PPG INDUSTRIES, INC. (US) | 1990-07-11 | — | — | EP | disclosed |