Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 11/20 | 0.42 |
| ▸ | CA1 known ✓ | P00915 | 9/20 | 0.42 |
| ▸ | CA12 known ✓ | O43570 | 5/20 | 0.42 |
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.42 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.39 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 7/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL165374 | 0.91 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL5959955 | 0.91 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL4818039 | 0.89 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL29152718 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1CA2CA9 | |
| Styrene SCHEMBL4274364 | 0.86 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL15313172 | 0.86 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL28165008 | 0.86 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL9453760 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL1672302 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1CA2CA1 | |
| Styrene SCHEMBL29220702 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603208-B1 | PATTERNED PRESSURE SENSITIVE ADHESIVE TRANSFER TAPE | MINNESOTA MINING & MFG (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5449540-A | Patterned pressure sensitive adhesive transfer tape | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-09-12 | — | — | US | disclosed |
| US-5344681-A | Patterned pressure sensitive adhesive transfer tape | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0603208-A1 | PATTERNED PRESSURE SENSITIVE ADHESIVE TRANSFER TAPE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-06-29 | — | — | EP | disclosed |
| WO-1993005123-A1 | PATTERNED PRESSURE SENSITIVE ADHESIVE TRANSFER TAPE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-03-18 | — | — | WO | disclosed |