Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 17/20 | 0.67 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309189 | 0.80 | TPH1 (1.00) | TPH1 | |
| SCHEMBL309188 | 0.80 | TPH1 (1.00) | TPH1 | |
| SCHEMBL320652 | 0.80 | TPH1 (1.00) | TPH1 | |
| SCHEMBL12694100 | 0.70 | TPH1 (0.78) | TPH1 | |
| SCHEMBL14969125 | 0.70 | TPH1 (1.00) | TPH1 | |
| SCHEMBL14969126 | 0.70 | TPH1 (1.00) | TPH1 | |
| SCHEMBL3408238 | 0.70 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308510 | 0.70 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308509 | 0.70 | TPH1 (1.00) | TPH1 | |
| SCHEMBL320797 | 0.69 | TPH1 (0.69) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274261-A1 | METHODS FOR TREATING PULMONARY HYPERTENSION | LEXICON PHARMACEUTICALS, INC. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274261-A1 | METHODS FOR TREATING PULMONARY HYPERTENSION | TPH1, TPH2, PTGIS | TPH1 1/4885IDH1 723/4885P2RX3 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.