Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491128 | 0.86 | ALOX5 (0.64) | MAPTALOX5POLBTDP1NPC1 | |
| SCHEMBL30006546 | 0.85 | ALDH1A1 (0.52) | ALOX5POLBTDP1NPC1RAB9A | |
| SCHEMBL29081751 | 0.82 | POLB (0.48) | POLBTDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL305162 | 0.81 | MAPT (0.68) | MAPTALOX5TDP1NPC1RAB9A | |
| SCHEMBL26023562 | 0.81 | MAPT (0.68) | MAPTALOX5TDP1NPC1RAB9A | |
| SCHEMBL8865449 | 0.81 | APLNR (0.56) | POLBALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL5834513 | 0.80 | ALDH1A1 (0.46) | POLBTDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL8865459 | 0.80 | APLNR (0.51) | POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL12285134 | 0.79 | TSHR (0.49) | MAPTPOLBTDP1NPC1ALDH1A1 | |
| SCHEMBL490819 | 0.79 | ALOX5 (0.64) | MAPTALOX5POLBTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557780-B2 | Monomethylvaline compounds capable of conjugation to ligands | SEATTLE GENETICS, INC. (US) | 2013-10-15 | — | — | US | disclosed |