Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 5/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17133396 | 0.77 | ALDH1A1 (0.52) | LMNAHPGDMEN1KMT2ANPC1 | |
| SCHEMBL15313667 | 0.76 | CA2 (0.42) | NPC1RAB9AALDH1A1CA1CA2 | |
| SCHEMBL21164867 | 0.74 | ERN1 (0.50) | LMNAHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL17133355 | 0.74 | NPC1 (0.52) | LMNAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL18840151 | 0.73 | ALDH1A1 (0.40) | LMNAHPGDMEN1KMT2ANPC1 | |
| SCHEMBL6737359 | 0.73 | ACHE (0.40) | NPC1RAB9AMAPT | |
| SCHEMBL3751505 | 0.69 | ALDH1A1 (0.59) | LMNAHPGDALDH1A1KDM4ETSHR | |
| SCHEMBL13894661 | 0.69 | ALDH1A1 (0.43) | LMNAHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL18085975 | 0.68 | NPC1 (0.42) | HPGDMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11799303 | 0.68 | ALDH1A1 (0.38) | LMNAHPGDMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |