Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA6 | P23280 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313665 | 0.76 | LMNA (0.36) | CA2NPC1RAB9ACA1SMN1; SMN2 | |
| SCHEMBL6737359 | 0.76 | ACHE (0.40) | NPC1RAB9APTPN1ACHEMAPT | |
| SCHEMBL6040717 | 0.75 | HTR2C (0.47) | NPC1RAB9AHTR2AHTR2CALDH1A1 | |
| SCHEMBL20263723 | 0.74 | NPC1 (0.32) | NPC1RAB9A | |
| SCHEMBL29654713 | 0.73 | HTR2C (0.45) | NPC1RAB9AHTR2AHTR2CTP53 | |
| SCHEMBL515378 | 0.73 | HTR2C (0.45) | NPC1RAB9AHTR2AHTR2CTP53 | |
| SCHEMBL6070144 | 0.72 | EGFR (0.40) | SMN1; SMN2PTPN1ACHEALDH1A1 | |
| SCHEMBL18198243 | 0.71 | NPC1 (0.54) | CA2NPC1RAB9ACA1HTR2C | |
| SCHEMBL6711039 | 0.71 | HTR2C (0.56) | NPC1RAB9AHTR2AHTR2C | |
| SCHEMBL25384659 | 0.71 | TUBB4A (0.35) | CA2CA4NPC1RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |