Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.54 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313675 | 1.00 | PLA2G2A (0.54) | PLA2G2APLA2G5FFAR1HTTBCL2 | |
| SCHEMBL15313668 | 0.98 | PLA2G2A (0.51) | PLA2G2APLA2G5FFAR1HTTBCL2 | |
| SCHEMBL9468232 | 0.89 | PLA2G2A (0.55) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL15314352 | 0.80 | BCL2 (0.54) | BCL2MCL1MEN1KMT2A | |
| SCHEMBL15313680 | 0.79 | FFAR1 (0.45) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL7775778 | 0.78 | PLA2G2A (0.53) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL7773832 | 0.78 | PLA2G2A (0.53) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL7773963 | 0.78 | PLA2G2A (0.53) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL9468226 | 0.78 | PLA2G2A (0.53) | PLA2G2APLA2G5FFAR1HTTHSD17B3 | |
| SCHEMBL28076672 | 0.77 | THRA (0.55) | PLA2G2APLA2G5FFAR1HTTHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |