Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313684 | 0.76 | HSP90AA1 (0.47) | BCL2MCL1HDAC8MAPTPTGER1 | |
| SCHEMBL15313688 | 0.75 | IGF1R (0.43) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313716 | 0.74 | FFAR1 (0.44) | BCL2BCL2L1MCL1ALOX15 | |
| SCHEMBL15313682 | 0.73 | RAB9A (0.51) | BCL2MCL1HDAC8NPC1ALDH1A1 | |
| SCHEMBL15313687 | 0.73 | SIGMAR1 (0.43) | BCL2BCL2L1ALOX15 | |
| SCHEMBL147459 | 0.72 | GAA (0.58) | ALDH1A1MAPTHPGDHTTNPSR1 | |
| SCHEMBL29767790 | 0.72 | GAA (0.58) | ALDH1A1MAPTHPGDHTTNPSR1 | |
| SCHEMBL15313692 | 0.71 | NPC1 (0.48) | BCL2BIDBCL2L1MCL1BAK1 | |
| SCHEMBL28417176 | 0.71 | PTGER1 (0.49) | TSHRHDAC8NPC1ALDH1A1MAPT | |
| SCHEMBL11145321 | 0.70 | GAA (0.56) | ALDH1A1MAPTHPGDHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |