Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | BAX | Q07812 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313694 | 0.87 | LTA4H (0.52) | SRD5A2LTA4HBCL2MCL1NR1H2 | |
| SCHEMBL15313712 | 0.81 | BCL2 (0.49) | SRD5A2LTA4HBCL2MCL1GRIN1 | |
| SCHEMBL15313715 | 0.81 | FFAR1 (0.46) | SRD5A2LTA4HBCL2MCL1FFAR1 | |
| SCHEMBL15313714 | 0.78 | RIPK1 (0.48) | SRD5A2LTA4HBCL2MCL1NR1H2 | |
| SCHEMBL15313711 | 0.78 | BCL2 (0.59) | SRD5A2LTA4HBCL2MCL1GRIN1 | |
| SCHEMBL15313716 | 0.78 | FFAR1 (0.44) | SRD5A2LTA4HBCL2MCL1FFAR1 | |
| SCHEMBL15313710 | 0.76 | LTA4H (0.50) | SRD5A2LTA4HNR1H2BAXGRIN1 | |
| SCHEMBL15313713 | 0.76 | BCL2 (0.47) | SRD5A2LTA4HBCL2MCL1GRIN1 | |
| SCHEMBL9325719 | 0.75 | BCL2 (0.62) | SRD5A2BCL2MCL1PTPN1 | |
| SCHEMBL15313693 | 0.74 | BCL2 (0.68) | SRD5A2BCL2MCL1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |