Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313859 | 0.81 | BCL2 (0.64) | BCL2LMNAMAPTTHRBSMN1; SMN2 | |
| SCHEMBL4069153 | 0.68 | ALDH1A1 (0.68) | LMNAMAPTNPSR1THRBSMN1; SMN2 | |
| SCHEMBL15313860 | 0.67 | BCL2L1 (0.67) | BCL2LMNAMAPTNPC1RAB9A | |
| SCHEMBL15313846 | 0.66 | BCL2 (0.57) | BCL2LMNAMAPTALDH1A1HTT | |
| SCHEMBL15313861 | 0.66 | BCL2 (0.63) | BCL2LMNAMAPTNPC1RAB9A | |
| SCHEMBL15313843 | 0.65 | BCL2L1 (0.83) | BCL2LMNAMAPTNPC1RAB9A | |
| SCHEMBL15313803 | 0.65 | BCL2 (1.00) | BCL2LMNAMAPTHTT | |
| Dimethylamine SCHEMBL9094128 | 0.64 | CASP6 (0.58) | LMNAMAPTNPSR1THRBSMN1; SMN2 | |
| SCHEMBL16615531 | 0.64 | ALDH1A1 (0.54) | LMNAMAPTNPSR1THRBSMN1; SMN2 | |
| SCHEMBL31143715 | 0.64 | LMNA (0.66) | LMNAMAPTNPSR1THRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |