Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 6/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313854 | 0.82 | BCL2L1 (0.64) | PARGMEN1KMT2APOLBBCL2L1 | |
| SCHEMBL15313869 | 0.71 | BCL2L1 (0.61) | MEN1KMT2ALMNAPOLBBCL2L1 | |
| SCHEMBL15313872 | 0.71 | BCL2 (0.50) | MEN1KMT2APOLBBCL2L1NPC1 | |
| SCHEMBL15313898 | 0.71 | MAOA (0.46) | PARGMEN1KMT2ALMNANPC1 | |
| SCHEMBL15313865 | 0.71 | BCL2L1 (0.67) | MEN1KMT2ALMNAPOLBBCL2L1 | |
| SCHEMBL15313873 | 0.69 | BCL2L1 (0.58) | PARGMEN1KMT2APOLBBCL2L1 | |
| SCHEMBL15313719 | 0.68 | BCL2 (0.61) | MEN1KMT2APOLB | |
| SCHEMBL15313871 | 0.68 | BCL2L1 (0.51) | MEN1KMT2ABCL2L1 | |
| SCHEMBL15313864 | 0.67 | BCL2L1 (0.65) | MEN1KMT2ALMNAPOLBBCL2L1 | |
| SCHEMBL17500085 | 0.67 | HDAC4 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |