Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PARG | Q86W56 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313875 | 0.84 | MAOA (0.47) | MAOANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15313899 | 0.75 | BCL2 (0.67) | MAOAKMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15313887 | 0.73 | BCL2 (0.56) | MAOANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL13576567 | 0.72 | MEN1 (0.63) | MAOANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15313867 | 0.71 | PARG (0.49) | NPC1RAB9AKMT2AMEN1PARG | |
| SCHEMBL15313854 | 0.70 | BCL2L1 (0.64) | NPC1RAB9AKMT2AMEN1PARG | |
| SCHEMBL4869345 | 0.68 | CA12 (0.68) | MAOANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15313972 | 0.67 | BCL2 (0.75) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL7643064 | 0.66 | NPC1 (0.81) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL22911505 | 0.66 | NPC1 (0.61) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |