Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.51 |
| ▸ | VEGFA | P15692 | 7/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340673 | 0.84 | EGLN1 (0.71) | EGLN1VEGFAMAPK14BRD4BRD2 | |
| SCHEMBL17340697 | 0.73 | VEGFA (0.67) | EGLN1VEGFAALDH1A1LMNAKDM4E | |
| SCHEMBL17340661 | 0.72 | VEGFA (0.57) | EGLN1VEGFAMAPK14ALDH1A1 | |
| SCHEMBL15314775 | 0.70 | KMT2A (0.47) | EGLN1VEGFAMAPK1ALDH1A1LMNA | |
| SCHEMBL17340685 | 0.68 | EGLN1 (0.50) | EGLN1VEGFAMAPK1MAPK14ALDH1A1 | |
| SCHEMBL271606 | 0.68 | EGLN1 (1.00) | EGLN1VEGFAKDM4EPOLB | |
| SCHEMBL272200 | 0.68 | EGLN1 (1.00) | EGLN1VEGFAKDM4EPOLB | |
| SCHEMBL15314773 | 0.68 | VEGFA (0.75) | EGLN1VEGFAALDH1A1POLB | |
| SCHEMBL17340662 | 0.65 | VEGFA (0.49) | EGLN1VEGFAALDH1A1 | |
| SCHEMBL15314777 | 0.65 | CNR2 (0.42) | EGLN1VEGFAMAPK14ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952192-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2649998-B1 | Prolyl hydroxylase inhibitors | AERPIO THERAPEUTICS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649998-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2013-10-16 | — | — | EP | disclosed |