Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20545522 | 0.87 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2NPC1MAPK1TP53 | |
| SCHEMBL10118118 | 0.81 | ALDH1A1 (0.53) | SMN1; SMN2MAPK1NPSR1HPGDALDH1A1 | |
| SCHEMBL14444268 | 0.81 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2MAPK1NPSR1MAPT | |
| SCHEMBL30093743 | 0.80 | ALOX15 (0.39) | RAB9ASMN1; SMN2NPC1MAPK1MAPT | |
| SCHEMBL27176343 | 0.80 | ALOX15 (0.39) | RAB9ASMN1; SMN2NPC1MAPK1MAPT | |
| SCHEMBL10877599 | 0.78 | TP53 (0.52) | RAB9ASMN1; SMN2NPC1MAPK1TP53 | |
| SCHEMBL2965820 | 0.75 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2NPC1MAPK1TP53 | |
| SCHEMBL30093760 | 0.74 | NCOA1 (0.38) | RAB9ASMN1; SMN2NPSR1MAPTHPGD | |
| SCHEMBL11397002 | 0.74 | TSHR (0.40) | RAB9ANPC1MAPTHPGDALDH1A1 | |
| SCHEMBL21855932 | 0.74 | BRD4 (0.42) | RAB9ASMN1; SMN2MAPK1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013154832-A2 | 2-PYRIMIDINE THIOESTERS AND THIOCARBONATES AS SKIN BRIGHTENING AGENTS | EASTMAN CHEMICAL COMPANY (US) | 2013-10-17 | — | — | WO | disclosed |
| US-20130273183-A1 | 2-Pyrimidine Thioesters and Thiocarbonates as Skin Brightening Agents | EASTMAN CHEMICAL COMPANY (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130273183-A1 | 2-Pyrimidine Thioesters and Thiocarbonates as Skin Brightening Agents | EASTMAN CHEMICAL COMPANY (US) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130273183-A1 | 2-Pyrimidine Thioesters and Thiocarbonates as Skin Brightening Agents | TYR, MITF, TTPA | RAB9A 2570/4885SMN1; SMN2 2808/4885NPC1 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.