SCHEMBL15315998

SCHEMBL15315998

c1ccc(-c2nccn2-c2ccccc2-c2c3ccccc3cc3ccccc23)cc1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 1/20 0.43
MAPK10 P53779 1/20 0.43
KDR P35968 16/20 0.41
P2RX4 Q99571 1/20 0.40
FLT1 P17948 3/20 0.39
FLT4 P35916 3/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28813675 0.81 KDR (0.46) MAPK9MAPK10KDRFLT1FLT4
SCHEMBL27659057 0.80 P2RX4 (0.46) MAPK9MAPK10KDRP2RX4FLT1
SCHEMBL15315957 0.78 KDR (0.43) MAPK9MAPK10KDRFLT1FLT4
SCHEMBL15316042 0.76 KDR (0.42) MAPK9MAPK10KDRFLT1FLT4
SCHEMBL15316093 0.74 KDR (0.36) MAPK9MAPK10KDRFLT1FLT4
SCHEMBL15316006 0.74 KMT2A (0.38) MAPK9MAPK10KDRP2RX4MEN1
SCHEMBL15316007 0.73 HTR2C (0.43) MAPK9MAPK10KDRP2RX4FLT1
SCHEMBL822887 0.71 KDR (0.41) MAPK9MAPK10KDRP2RX4FLT1
SCHEMBL15315970 0.71 KDR (0.51) MAPK9MAPK10KDRFLT1FLT4
SCHEMBL11822572 0.71 KDR (0.44) MAPK9MAPK10KDRP2RX4FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130270541-A1 IMIDAZOLE COMPOUND PRODUCTION METHOD, IMIDAZOLE COMPOUND, IMIDAZOLE-BASED COMPOUND, ORGANIC METAL COMPLEX, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, AND LIGHTING DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2013-10-17 US disclosed
US-20130270541-A1 IMIDAZOLE COMPOUND PRODUCTION METHOD, IMIDAZOLE COMPOUND, IMIDAZOLE-BASED COMPOUND, ORGANIC METAL COMPLEX, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, AND LIGHTING DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2013-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130270541-A1 IMIDAZOLE COMPOUND PRODUCTION METHOD, IMIDAZOLE COMPOUND, IMIDAZOLE-BASED COMPOUND, ORGANIC METAL COMPLEX, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, AND LIGHTING DEVICE NFXL1, NFE2L2, ZC3HAV1L MAPK9 1332/4885MAPK10 2857/4885KDR 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.