Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25702598 | 0.80 | KMT2A (0.49) | PTGESALOX5KDM4EMEN1ALDH1A1 | |
| SCHEMBL15858905 | 0.76 | ATM (0.42) | PTGESKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3482958 | 0.76 | PTGES (0.53) | PTGESALOX5KDM4EMEN1ALDH1A1 | |
| SCHEMBL27729713 | 0.75 | MMP3 (0.57) | PTGESALOX5ALDH1A1TAS2R14HTR2A | |
| SCHEMBL3483152 | 0.74 | PTGES (0.51) | PTGESALOX5KDM4EMEN1ALDH1A1 | |
| Bicarbonate SCHEMBL15225927 | 0.72 | RAB9A (0.54) | ALDH1A1KMT2APOLBRAB9A | |
| Bicarbonate SCHEMBL9058314 | 0.71 | PTGES (0.48) | PTGESALOX5KDM4EMEN1ALDH1A1 | |
| SCHEMBL3968836 | 0.71 | NPSR1 (0.58) | KDM4EMEN1ALDH1A1KMT2AESR1 | |
| SCHEMBL8773484 | 0.70 | HDAC1 (0.61) | PTGESKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL12077868 | 0.70 | TAS2R14 (0.52) | PTGESKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292639-B1 | Tubulisine derivatives as anticancer drugs | KEMOTECH S R L (IT) | 2014-09-03 | — | — | EP | disclosed |
| US-8580820-B2 | Tubulysin compounds with high cytotoxicity, pharmaceutical compositions thereof, and method of use thereof | KEMTECH S.R.L. (IT) | 2013-11-12 | — | — | US | disclosed |
| US-20110200581-A1 | PHARMACEUTICAL COMPOSITIONS | KEMOTECH S.r.I (IT) | 2011-08-18 | — | — | US | disclosed |
| EP-2292639-A1 | Tubulisine derivatives as anticancer drugs | Kemotech S.r.l. (IT) | 2011-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110200581-A1 | PHARMACEUTICAL COMPOSITIONS | NR1H3, NR1H2, CCR8 | PTGES 4442/4885ALOX5 1241/4885KDM4E 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.