SCHEMBL15317554

SCHEMBL15317554

CCCCCCCc1cnc(C(F)(F)Oc2ccc(C(F)(F)Oc3cc(F)c(S(F)(F)(F)(F)F)c(F)c3)nc2)nc1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.36
RAB9A P51151 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
STAT3 P40763 1/20 0.33
ATM Q13315 1/20 0.33
MOGAT2 Q3SYC2 5/20 0.33
RARB P10826 1/20 0.30
CYP2C9 P11712 1/20 0.30
PLA2G4A P47712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15317563 0.93 RAB9A (0.43) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL14226626 0.81 MAPT (0.30) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317553 0.80 RARB (0.34) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317561 0.79 MAPT (0.39) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317542 0.78 MAPT (0.33) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317545 0.76 MAPT (0.34) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317550 0.75 MAPT (0.33) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317549 0.74 MAPT (0.36) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317559 0.73 RAB9A (0.40) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL12357612 0.72 ALOX5AP (0.37) MAPTRAB9AL3MBTL1CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9133397-B2 Tricyclic compound having a plurality of CF2O bonding groups, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2015-09-15 US disclosed
US-9133397-B2 Tricyclic compound having a plurality of CF2O bonding groups, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2015-09-15 US disclosed
US-20130271719-A1 TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-17 US disclosed
US-20130271719-A1 TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-17 US disclosed