SCHEMBL15323907

SCHEMBL15323907

O=C1Nc2ccc(F)cc2OC12CC2

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.46
MAPT P10636 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43
BRD4 O60885 3/20 0.41
OTUD7B Q6GQQ9 4/20 0.39
AKR1B1 P15121 2/20 0.38
AKR1B10 O60218 1/20 0.38
AKR1A1 P14550 1/20 0.38
HTR2C P28335 2/20 0.37
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
LRRK2 Q5S007 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24427664 0.80 LMNA (0.43) KMT2AMAPTBRD4HTR2CCA12
SCHEMBL24427221 0.80 HTT (0.45) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL900430 0.79 KMT2A (0.45) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL29240343 0.78 KMT2A (0.44) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL19030688 0.78 BRD4 (0.61) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL29706799 0.78 BRD4 (0.61) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL16863790 0.77 BRD4 (0.47) KMT2AMAPTCYP1A2CYP2C19BRD4
SCHEMBL16163265 0.75 ALOX5 (0.43) KMT2AMAPTBRD4OTUD7B
SCHEMBL17996438 0.75 ALPL (0.47) KMT2AMAPTCYP1A2CYP2C19AKR1B1
SCHEMBL20693111 0.74 ESR1 (0.38) KMT2AOTUD7BLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111132979-B Benzoxazinone derivatives as herbicides 瑞戴格作物保护公司 2024-03-26 CN disclosed
US-11261177-B2 Benzoxazinone derivatives useful as herbicides REDAG CROP PROTECTION LTD (GB) 2022-03-01 US disclosed
EP-3658551-B1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROT LTD (GB) 2022-01-19 EP disclosed
EP-3658551-B1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROT LTD (GB) 2022-01-19 EP disclosed
US-20200172527-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROT LTD (GB) 2020-06-04 US disclosed
US-20200172527-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROT LTD (GB) 2020-06-04 US disclosed
EP-3658551-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES Redag Crop Protection Ltd (GB) 2020-06-03 EP disclosed
CN-111132979-A Benzoxazinone derivatives as herbicides 瑞戴格作物保护公司 2020-05-08 CN disclosed
WO-2019020987-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROTECTION LTD. (GB) 2019-01-31 WO disclosed
WO-2019020987-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES REDAG CROP PROTECTION LTD. (GB) 2019-01-31 WO disclosed
WO-2013153539-A1 TRICYCLIC COMPOUNDS AS TEC KINASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2013-10-17 WO disclosed
WO-2013153539-A1 TRICYCLIC COMPOUNDS AS TEC KINASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2013-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200172527-A1 BENZOXAZINONE DERIVATIVES USEFUL AS HERBICIDES CBR3, CBR1, CYP4X1 KMT2A 2094/4885MAPT 4014/4885CYP1A2 54/4885
US-11261177-B2 Benzoxazinone derivatives useful as herbicides CBR3, CYP4X1, DDT KMT2A 2113/4885MAPT 3939/4885CYP1A2 51/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.