Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 2/20 | 0.35 |
| ▸ | CPT1A | P50416 | 2/20 | 0.35 |
| ▸ | OTC | P00480 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 5/20 | 0.34 |
| ▸ | NOS1 | P29475 | 5/20 | 0.34 |
| ▸ | NOS2 | P35228 | 5/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CRAT | P43155 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27902011 | 0.92 | SLC22A16 (0.50) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL27492468 | 0.91 | SLC22A16 (0.49) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL28276672 | 0.90 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL15323970 | 0.87 | OTC (0.36) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL22577747 | 0.87 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL1462462 | 0.87 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL15323292 | 0.87 | MAPT (0.37) | SLC22A16OTCNOS3NOS1NOS2 | |
| Arginine SCHEMBL15322472 | 0.85 | OTC (0.39) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL15324001 | 0.85 | OTC (0.34) | SLC22A16OTCNOS3NOS1NOS2 | |
| Arginine SCHEMBL15322680 | 0.85 | MAPT (0.40) | SLC22A16OTCNOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |