Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.50 |
| ▸ | CPT2 | P23786 | 2/20 | 0.41 |
| ▸ | CPT1A | P50416 | 2/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRAT | P43155 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27492468 | 0.99 | SLC22A16 (0.49) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL1462462 | 0.94 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL22577747 | 0.94 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL28276672 | 0.93 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL15323966 | 0.92 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS3 | |
| L-Citrulline SCHEMBL25363292 | 0.90 | SLC22A16 (0.53) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL7785699 | 0.86 | OTC (0.43) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL5050788 | 0.86 | OTC (0.43) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL15323382 | 0.84 | MAPT (0.39) | SLC22A16OTCNOS3NOS1NOS2 | |
| Acetylcarnitine SCHEMBL948558 | 0.84 | MEN1 (0.56) | CPT2CPT1AOTCNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102843922-B | The neuroprotective of Xiao base Zhi Fang Suan – cognitive decline and/or suppression | NITROMEGA CORP. (US) | 2015-12-16 | — | — | CN | disclosed |
| CN-102843922-A | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline | NITROMEGA CORP | 2012-12-26 | — | — | CN | disclosed |