Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27902011 | 0.93 | SLC22A16 (0.50) | SLC22A16MAPTCPT2CPT1AOTC | |
| Arginine SCHEMBL27492468 | 0.92 | SLC22A16 (0.49) | SLC22A16MAPTCPT2CPT1AOTC | |
| Arginine SCHEMBL15323966 | 0.90 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS3 | |
| Arginine SCHEMBL1462462 | 0.88 | SLC22A16 (0.44) | SLC22A16MAPTCPT2CPT1AOTC | |
| Arginine SCHEMBL22577747 | 0.88 | SLC22A16 (0.44) | SLC22A16MAPTCPT2CPT1AOTC | |
| Arginine SCHEMBL16099880 | 0.87 | OTC (0.44) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL16099882 | 0.87 | OTC (0.44) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL19459580 | 0.87 | OTC (0.44) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL15323382 | 0.85 | MAPT (0.39) | SLC22A16MAPTOTCNOS3NOS1 | |
| Arginine SCHEMBL15322680 | 0.84 | MAPT (0.40) | SLC22A16MAPTOTCNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109394745-A | A kind of composition comprising L-carnitine and beta-hydroxy-butanoic acid compound | 博瑞生物医药（苏州）股份有限公司 | 2019-03-01 | — | — | CN | disclosed |