Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.49 |
| ▸ | CPT2 | P23786 | 2/20 | 0.40 |
| ▸ | CPT1A | P50416 | 2/20 | 0.40 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 4/20 | 0.38 |
| ▸ | NOS3 | P29474 | 3/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27902011 | 0.99 | SLC22A16 (0.50) | SLC22A16CPT2CPT1AOTCNOS1 | |
| Arginine SCHEMBL22577747 | 0.93 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS1 | |
| Arginine SCHEMBL1462462 | 0.93 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCNOS1 | |
| Arginine SCHEMBL28276672 | 0.92 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS1 | |
| Arginine SCHEMBL15323966 | 0.91 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS1 | |
| L-Citrulline SCHEMBL25363292 | 0.89 | SLC22A16 (0.53) | SLC22A16CPT2CPT1AOTCNOS1 | |
| Arginine SCHEMBL7785699 | 0.85 | OTC (0.43) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL5050788 | 0.85 | OTC (0.43) | OTCNOS1NOS2NOS3DDAH1 | |
| Acetylcarnitine SCHEMBL620955 | 0.84 | MEN1 (0.55) | CPT2CPT1AOTCNOS1NOS2 | |
| Acetylcarnitine SCHEMBL27934793 | 0.84 | MEN1 (0.55) | CPT2CPT1AOTCNOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1162397-C | Therapeutically and/or nutritionaly enhanced derivatives of active ingredients and orally administrable compsns. contg. same | �����ι�˾ | 2004-08-18 | — | — | CN | disclosed |
| CN-1356976-A | Therapeutically and/or nutritionaly enhanced derivatives of active ingredients and orally administrable compsns. contg. same | BIOSALTS SRL (IT) | 2002-07-03 | — | — | CN | disclosed |