Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 2/20 | 0.37 |
| ▸ | CPT1A | P50416 | 2/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL22577747 | 1.00 | SLC22A16 (0.44) | SLC22A16CPT2CPT1AOTCPTGS1 | |
| Arginine SCHEMBL27902011 | 0.94 | SLC22A16 (0.50) | SLC22A16CPT2CPT1AOTCNOS2 | |
| Arginine SCHEMBL27492468 | 0.93 | SLC22A16 (0.49) | SLC22A16CPT2CPT1AOTCNOS2 | |
| Arginine SCHEMBL28276672 | 0.88 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS2 | |
| Carnitine SCHEMBL1462464 | 0.87 | SLC22A16 (0.43) | SLC22A16CPT2CPT1ACPT1BCYP2C19 | |
| Arginine SCHEMBL15323966 | 0.87 | SLC22A16 (0.43) | SLC22A16CPT2CPT1AOTCNOS2 | |
| L-Citrulline SCHEMBL25363292 | 0.85 | SLC22A16 (0.53) | SLC22A16CPT2CPT1AOTCNOS2 | |
| Carnitine SCHEMBL20745548 | 0.83 | SLC22A16 (0.65) | SLC22A16CPT2CPT1APTGS1SLC7A11 | |
| Arginine SCHEMBL5586520 | 0.83 | PTGS1 (0.52) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Levocarnitine SCHEMBL20745546 | 0.83 | SLC22A16 (0.65) | SLC22A16CPT2CPT1APTGS1SLC7A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494075-A2 | TEMPLATED NANOCONJUGATES | Northwestern University (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2473160-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | Northwestern University (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011053940-A2 | TEMPLATED NANOCONJUGATES | NORTHWESTERN UNIVERSITY (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011028850-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | NORTHWESTERN UNIVERSITY (US) | 2011-03-10 | — | — | WO | disclosed |