Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11179315 | 1.00 | ALDH1A1 (0.37) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL15325061 | 0.90 | MAPK1 (0.36) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL7392445 | 0.90 | MAPK1 (0.36) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL15325068 | 0.90 | LMNA (0.37) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL10953253 | 0.90 | LMNA (0.37) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL7392441 | 0.90 | MAPK1 (0.36) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL7392443 | 0.90 | MAPK1 (0.36) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL12037366 | 0.90 | LMNA (0.37) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL15325080 | 0.89 | MAPK1 (0.35) | ALDH1A1POLBLMNAHSD17B10MAPK1 | |
| SCHEMBL30706721 | 0.86 | POLB (0.36) | ALDH1A1POLBLMNAHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120818-B2 | Process and intermediates for preparing macrolactams | MERCK SHARP & DOHME CORP. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20130274463-A1 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS | MERCK SHARP & DOHME CORP. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274463-A1 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS | EMG1, MRPS18B, MLN | ALDH1A1 3301/4885POLB 2182/4885LMNA 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.