Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532872 | 0.93 | FAAH (0.50) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532848 | 0.92 | FAAH (0.61) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532863 | 0.92 | FAAH (0.49) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532764 | 0.92 | FAAH (0.49) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL3487739 | 0.92 | FAAH (0.49) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532795 | 0.92 | FAAH (0.52) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532641 | 0.90 | MGLL (0.55) | FAAHPARP14MGLLOPRK1KCNH2 | |
| SCHEMBL1532788 | 0.85 | FAAH (0.50) | FAAHMGLL | |
| SCHEMBL29976303 | 0.84 | FAAH (0.71) | FAAHMGLL | |
| SCHEMBL1532565 | 0.84 | FAAH (0.71) | FAAHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849773-B1 | Piperazine derivatives for the treatment of urinary incontinence and pain | ASTELLAS PHARMA INC (JP) | 2013-10-16 | — | — | EP | claimed |
| EP-2564849-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH PAINS IN URINARY ORGANS | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | claimed |
| US-20130030006-A1 | AGENT FOR PREVENTING OR TREATING DISEASES ACCOMPANIED BY URINARY PAIN | ASTELLAS PHARMA INC. (JP) | 2013-01-31 | — | — | US | claimed |
| CN-102858340-A | Prophylactic or therapeutic agent for diseases associated with pains in urinary organs | ASTELLAS PHARMA INC | 2013-01-02 | — | — | CN | claimed |
| US-7915261-B2 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound | ASTELLAS PHARMA, INC. (JP) | 2011-03-29 | — | — | US | claimed |
| US-20100009971-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound | ASTELLAS PHARMA INC. (JP) | 2010-01-14 | — | — | US | claimed |
| US-20080306046-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative | FMC CORPORATION (US) | 2008-12-11 | — | — | US | claimed |
| EP-1849773-B1 | Piperazine derivatives for the treatment of urinary incontinence and pain | ASTELLAS PHARMA INC (JP) | 2013-10-16 | — | — | EP | disclosed |
| EP-2607362-A1 | Piperidine and piperazine carboxylates as FAAH inhibitors | Astellas Pharma Inc. (JP) | 2013-06-26 | — | — | EP | disclosed |
| EP-2564849-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH PAINS IN URINARY ORGANS | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130030006-A1 | AGENT FOR PREVENTING OR TREATING DISEASES ACCOMPANIED BY URINARY PAIN | ASTELLAS PHARMA INC. (JP) | 2013-01-31 | — | — | US | disclosed |
| CN-102858340-A | Prophylactic or therapeutic agent for diseases associated with pains in urinary organs | ASTELLAS PHARMA INC | 2013-01-02 | — | — | CN | disclosed |
| US-7919495-B2 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound | ASTELLAS PHARMA, INC. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-7919494-B2 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound | ASTELLAS PHARMA, INC. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-7915261-B2 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound | ASTELLAS PHARMA, INC. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-20100009971-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound | ASTELLAS PHARMA INC. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-20100009972-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound | ASTELLAS PHARMA INC. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-20080306046-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative | FMC CORPORATION (US) | 2008-12-11 | — | — | US | disclosed |
| EP-1849773-A1 | PYRIDYL NON-AROMATIC NITROGENATED HETEROCYCLIC-1-CARBOXYLATE ESTER DERIVATIVE | Astellas Pharma Inc. (JP) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306046-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative | FAAH, FAAH2, APEH | FAAH 1/4885PARP14 2325/4885MGLL 447/4885 |
| US-20100009972-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound | FAAH, FAAH2, CNR2 | FAAH 1/4885PARP14 1629/4885MGLL 578/4885 |
| US-20130030006-A1 | AGENT FOR PREVENTING OR TREATING DISEASES ACCOMPANIED BY URINARY PAIN | FAAH, FAAH2, PTGS1 | FAAH 1/4885PARP14 2005/4885MGLL 731/4885 |
| US-20100009971-A1 | Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound | FAAH, FAAH2, CNR1 | FAAH 1/4885PARP14 1606/4885MGLL 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.